skin_keratinocytic

TX   Primary tumour cannot be assessed
T0   No evidence of primary tumour
Tis   Carcinoma in situ
T1   Tumour 2 cm or less in greatest dimension**
T2   Tumour more than 2 cm or two or more high risks
T3    Skeleton, Maxilla, Mandible, Orbit, Temporal bone
T4    頭蓋底, 中軸骨格，神経周囲

Note: In the case of multiple simultaneous tumours,
the tumour with the highest T category is classified and
the number of separate tumours is indicated in parentheses, e.g., T2(5).

**T1ではhigh risk要因 2個未満　AJCC
厚さ > 2 mm, Clark level IV Pn L Ear hear-bearing upper lip G3-4

N – Regional lymph nodes
NX   Regional lymph nodes cannot be assessed
N0   No regional lymph node metastasis
N1    single ≤ 3 cm
N2    single/multiple ≤ 6 cm
N3    >6 cm

I-II T1-2
III T3 or N1
IV N2-3 T4 M1

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Basal cell carcinoma 8090/3

BCCはEMA- Ber-EP4+
SCCはEMA+ Ber-EP4-
(Beer TW et al. Histopathology 2000;37:218-223).

Superficial basal cell carcinoma 8091/3

BCC_figures/BCC_nodular.png

solid

嚢胞を伴う粘液変性や腺様篩状構造がときにみられる
mucinous degeneration with cysts or adenoid cribriform pattern
Nodular (solid) basal cell carcinoma 8097/3

BCC_figures/BCC_micronodular.png

Micronodular basal cell carcinoma 8090/3
3〜10 cells。切除断端注意。

BCC_figures/BCC_infiltrating.png

Infiltrating basal cell carcinoma 8092/3
cord in the collagen bundles
microcystic adnexal carcinoma等と形態的に重なる

BCC_figures/BCC_fibroepithelial.png

Fibroepithelial basal cell carcinoma 8093/3
背中に多い

BCC_figures/BCC_adnexal1.png

sebaceous differentiation
Basal cell carcinoma with adnexal differentiation 8098/3

Basosquamous carcinoma 8094/3
SCCに近い像。転移リスクあり。脂腺分化がみられることがある。脂腺癌との鑑別も問題となるので，perilipinなども染めよう。

BCC_figures/BCC_keratotic.png

Keratotic basal cell carcinoma 8090/3
無数の小ケラチン嚢腫を形成

BCC_figures/BCC_cystic.png

Cystic variant

BCC_figures/BCC_adenoid.png

adenoid variant
thin strands in a reticulate pattern, with or without stromal mucin

BCC_figures/BCC_morphea.png

sclerosing/morpheiform variant
Keloidal collagen, actin+/- in shiny plaque

infundibulocystic

BCC_figures/BCCC_pigmented.png

pigmented
melanophage in stroma

signet-ring
granuar cell
giant (monster) cell
adamantanoid
neuroendocrine
schwannoid

BCC_figures/BCC_rosette.png

BCC with rosettes

Squamous cell carcinoma 8070/3

Acantholytic squamous cell carcinoma 8075/3
Spindle-cell squamous cell carcinoma 8074/3
Verrucous squamous cell carcinoma 8051/3
Pseudovascular squamous cell carcinoma 8075/3

Adenosquamous carcinoma 8560/3

Bowen disease 8081/2

Bowenoid papulosis

乳房外Paget病の病期分類案 (日本)

T1 表皮内癌
T2 微小浸潤
T3 結節性浸潤
T4 脈管浸潤あり

N1片側リンパ節
N2両側リンパ節

IA T1
IB T2
II T3
III T4 OR N1
IV N2 OR M1

乳房外Paget病の病期分類(UICC)

乳房外Pagetを皮膚腫瘍として分類するのか外陰癌として分類するのか
明確でない　
皮膚腫瘍として記載するならCutaneous SCCに準じて記載

Cutaneous SCC and Other Cutaneous carcinoma

乳房外Paget病の病期分類案 (日本)

乳房外Paget病の病期分類(UICC)