Soft tissue sarcoma

T1a表在(表層筋膜より表層) 5 cm以下
T1b
T2a
T2b

Stage IA         T1 & G1
Stage IB         T2 & G1
Stage IIA        T1 & G2-3
Stage IIB        T2 & G2
Stage III         T2 & G3
                     N1
Stage IV        M1

FNCLCC Grading System: Definition of Parameters
(FNCLCC = Federation Nationale des Centres de Lutte le Cancer)

Grade1: 2-3
Grade2: 4-5
Grade3: 6, 7, 8

Differentiation
Score 1: 正常に近い
Score 2: 組織型が判別できる
Score 3: 分化が不明 (滑膜肉腫,胎児肉腫,未分化肉腫)

分裂像 (強拡大視野 = 0.1734 mm^2として)[視野数22の場合...1.37倍して]
0-9/10 hpf [12個まで]
10-19/10 hpf [26個まで]
≥20/10 hpf [27個以上]

腫瘍壊死
0点 壊死なし
1点 壊死1〜50%以下
2点 >50%

Grade 1: Well-differentiated liposarcoma, Well-differentiated leiomyosarcoma
Grade 2: Myxoid liposarcoma, Myxofibrosarcoma, Conventional leiomyosarcoma, Fibrosarcoma
Grade 3: Round cell liposarcoma, pleomorphic liposarcoma, epithelioid leiomyosarcoma, synovial sarcoma, rhabdomyosarcoma, mesenchymal chondrosarcoma, extraskeletal osteosarcoma, Ewing/PNET, rhabdoid tumor, undifferentiated sarcoma

FRENCH GRADING SYSTEM FOR SOFT TISSUE SARCOMAS

FNCLCC Grading System: Definition of Parameters
(FNCLCC = Federation Nationale des Centres de Lutte le Cancer)

FNCLCC Grading System: Tumor Differentiation Score According to Histologic Type
Well-differentiated liposarcoma    1
Myxoid liposarcoma    2
Round cell liposarcoma    3
Pleomorphic liposarcoma    3
Well-differentiated fibrosarcoma    1
Conventional fibrosarcoma    2
Poorly-differentiated fibrosarcoma    3
Myxofibrosarcoma    2
Pleomorphic MFH with storiform pattern    2
Pleomorphic MFH with no storiform pattern    3
Giant cell MFH    3
Well-differentiated leiomyosarcoma    1
Conventional leiomyosarcoma    2
Poorly-differentiated/pleomorphic/epithelioid leiomyosarcoma    3
Embryonal/alveolar/pleomorphic rhabdomyosarcoma    3
Mesenchymal chondrosarcoma    3
Osteosarcoma    3
PNET    3
Malignant triton tumor    3
Synovial sarcoma    3
Well-differentiated/conventional angiosarcoma    2
Poorly-differentiated/epithelioid angiosarcoma    3
Epithelioid sarcoma    3
Clear cell sarcoma    3

MFH = malignant fibrous histiocytoma
PNET = primitive neuroectodermal tumor

Bone sarcoma

T1: 8cm以下
T2: 8cmより大
T3: 原発骨から不連続な病変

IA: T1, G1/2
IB: T2-3, G1/2
II: T1-2, G3/4
III: T3, G3/4
IVa: M1a(肺転移)
IVb:N1(リンパ節転移)かM1b(肺以外転移)