Soft tissue sarcoma
T1a表在(表層筋膜より表層) 5 cm以下
T1b
T2a
T2b
Stage IA T1 & G1
Stage IB T2 & G1
Stage IIA T1 & G2-3
Stage IIB T2 & G2
Stage III T2 & G3
N1
Stage IV M1
FNCLCC Grading System: Definition of Parameters
(FNCLCC = Federation Nationale des Centres de Lutte le Cancer)
Grade1: 2-3
Grade2: 4-5
Grade3: 6, 7, 8
Differentiation
Score 1: 正常に近い
Score 2: 組織型が判別できる
Score 3: 分化が不明 (滑膜肉腫,胎児肉腫,未分化肉腫)
分裂像 (強拡大視野 = 0.1734 mm^2として)[視野数22の場合...1.37倍して]
0-9/10 hpf [12個まで]
10-19/10 hpf [26個まで]
≥20/10 hpf [27個以上]
腫瘍壊死
0点 壊死なし
1点 壊死1〜50%以下
2点 >50%
Grade 1: Well-differentiated liposarcoma, Well-differentiated
leiomyosarcoma
Grade 2: Myxoid liposarcoma, Myxofibrosarcoma, Conventional
leiomyosarcoma, Fibrosarcoma
Grade 3: Round cell liposarcoma, pleomorphic liposarcoma,
epithelioid leiomyosarcoma, synovial sarcoma, rhabdomyosarcoma,
mesenchymal chondrosarcoma, extraskeletal osteosarcoma,
Ewing/PNET, rhabdoid tumor, undifferentiated sarcoma
FRENCH GRADING SYSTEM FOR SOFT TISSUE SARCOMAS
FNCLCC Grading System: Definition of Parameters
(FNCLCC = Federation Nationale des Centres de Lutte le Cancer)
FNCLCC Grading System: Tumor Differentiation Score According to
Histologic Type
Well-differentiated liposarcoma 1
Myxoid liposarcoma 2
Round cell liposarcoma 3
Pleomorphic liposarcoma 3
Well-differentiated fibrosarcoma 1
Conventional fibrosarcoma 2
Poorly-differentiated fibrosarcoma 3
Myxofibrosarcoma 2
Pleomorphic MFH with storiform pattern 2
Pleomorphic MFH with no storiform pattern 3
Giant cell MFH 3
Well-differentiated leiomyosarcoma 1
Conventional leiomyosarcoma 2
Poorly-differentiated/pleomorphic/epithelioid
leiomyosarcoma 3
Embryonal/alveolar/pleomorphic rhabdomyosarcoma
3
Mesenchymal chondrosarcoma 3
Osteosarcoma 3
PNET 3
Malignant triton tumor 3
Synovial sarcoma 3
Well-differentiated/conventional angiosarcoma 2
Poorly-differentiated/epithelioid angiosarcoma 3
Epithelioid sarcoma 3
Clear cell sarcoma 3
MFH = malignant fibrous histiocytoma
PNET = primitive neuroectodermal tumor
Bone sarcoma
T1: 8cm以下
T2: 8cmより大
T3: 原発骨から不連続な病変
IA: T1, G1/2
IB: T2-3, G1/2
II: T1-2, G3/4
III: T3, G3/4
IVa: M1a(肺転移)
IVb:N1(リンパ節転移)かM1b(肺以外転移)