膵癌組織型(WHO第5版に準拠)

Serous cystadenoma NOS
    macrocystic (oligocystic)
    solid
    VHL syndrome-associated serous cystic neoplasm
    Mixed serous-neuroendocrine neoplasm
Serous cystadenocarcinoma NOS

Pancreatic mucinous cystic neoplasm (MCN)
    with low-grade dysplasia
    with high-grade dysplasia
    with associated invasive carcinoma

Intraductal papillary mucinous neoplasm (IPMN)
    with low-grade dysplasia
    with high-grade dysplasia
    with associated invasive carcinoma
Intraductal papillary carcinoma, non-invasive
Intraductal papillary carcinoma, invasive

Intraductal tubulopapillary neoplasm (ITPN)
Intraductal papillary neoplasm with associated invasive carcinoma

Pancreatic intraepithelial neoplasia (PanIN)
    Glandular intraepithelial neoplasia, low grade
    Glandular intraepithelial neoplasia, high grade

Intraductal oncocytic papillary neoplasm (IOPN)
    IOPN NOS
    IOPN with associated invasive carcinoma

Pancreatic ductal adenocarcinoma
    Ductal adenocarcinoma NOS
    Adenosquamous carcinoma
    Colloid carcinoma (mucinous non-cystic carcinoma)
    Undifferentiated carcinoma
        anaplastic type
        sarcomatoid type (spindle cell carcinoma)
        with osteoclast-like giant cells

Pancreatic acinar cell tumor

Acinar cystic transformation of the pancreas (acinar cell cystadenoma)
Acinar cell carcinoma (BCL10染色陽性は,BCL10のC末端を認識する抗体が,膵臓のリパーゼのC末端も認識する交差反応による)
    mixed acinar carcinoma
    mixed acinar-ductal carcinoma

Pancreatoblastoma

Solid-pseudopapillary neoplasm 充実性偽乳頭状腫瘍
 
Pancreatic neuroendocrine neoplasms (PanNENs)
    G1 PanNET, <2/2 mm^2, <3%
    G2 PanNET, 2-20, <20%
    G3 PanNET, >20, >20%
    PanNEC, EMA (MUC1)+, CEA+
    Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN)

non-functioning PanNETs
Insulinoma
Gastrinoma
VIPoma
Glucagonoma
Somatostatinoma
ACTH-producing NET
Serotonin-producing NET

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以下参考 旧分類:
Pancreatic intraepithelial neoplasia, grade分類 (AJSP 2001)が適応されるのは細径膵管のみ。

 PanIN-1A metaplasia (pyloric gland, goblet cell) mucinous ductal hyperplasia
                        tall columnar, flat
 PanIN-1B papillary hyperplasia
                        tall columnar, papillary or micropapillary

 PanIN-2 atypical hyperplasia low-grade dysplasia, moderate dysplasia
                        enlarged nuclei, pseudostratification, flat or papillary

 PanIN-3 Carcinoma in situ, high-grade dysplasia moderate to severe dysplasia
                        true cribriforming, budding, (出芽)luminal necrosis
                        mitoses, macronucleoli

pic1.jpg
Drawing by Jennifer Parsons

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WHO (2010)

Acinar cell cystadenoma
Serous cystadenoama

Pancreatic intraepithelial neoplasia, grade 3 (PanIN-3)

IIPMN with low- or intermediate-grade dysplasia    8453/0
IPMN with high-grade dysplasia    8453/2

Intraductal tubulopapillary neoplasm    8503/2

MCN with low- or intermediate-grade dysplasia    8470/0
MCN with high-grade dysplasia    8470/2

Ductal adenocarcinoma
    Adenosquamous ca.
    Colloid ca. (mucinous noncystic ca.)
    Hepatoid ca.
    Medullary ca.
    Signet ring cell ca.
    Undifferentiated ca.
    Undifferentiated ca. with osteoclast-like giant cells

Acinar cell carcinoma
Acinar cell cystadenocarcinoma

IPMN with an associated invasive carcinoma    8453/3

Mixed acinar-ductal ca.
            acinar-neuroendocrine
            acinar-neuroendocrine-ductal
            ductal-neuroendocrine

MCN with an associated invasive carcinoma    8470/3

Pancreatoblastoma

Serous cystadenocarcinoma

Solid-pseudopapillary neoplasm    8452/3

Panreatic neuroendocrine microadenoma    8150/0

NET G1    8240/3
NET G2    8249/3
Large cell NEC  
Small cell NEC

EC cel, serotonin-producing NET (carcinoid)
Gastrinoma
Glucagonoma
Insulinoma
Somatostatinoma
VIPoma

Mature teratoma    9080/0