膵癌組織型(WHO第5版に準拠)
Serous cystadenoma NOS
macrocystic (oligocystic)
solid
VHL syndrome-associated serous cystic neoplasm
Mixed serous-neuroendocrine neoplasm
Serous cystadenocarcinoma NOS
Pancreatic mucinous cystic neoplasm (MCN)
with low-grade dysplasia
with high-grade dysplasia
with associated invasive carcinoma
Intraductal papillary mucinous neoplasm (IPMN)
with low-grade dysplasia
with high-grade dysplasia
with associated invasive carcinoma
Intraductal papillary carcinoma, non-invasive
Intraductal papillary carcinoma, invasive
Intraductal tubulopapillary neoplasm (ITPN)
Intraductal papillary neoplasm with associated invasive carcinoma
Pancreatic intraepithelial neoplasia (PanIN)
Glandular intraepithelial neoplasia, low grade
Glandular intraepithelial neoplasia, high grade
Intraductal oncocytic papillary neoplasm (IOPN)
IOPN NOS
IOPN with associated invasive carcinoma
Pancreatic ductal adenocarcinoma
Ductal adenocarcinoma NOS
Adenosquamous carcinoma
Colloid carcinoma (mucinous non-cystic carcinoma)
Undifferentiated carcinoma
anaplastic type
sarcomatoid type (spindle cell carcinoma)
with osteoclast-like giant cells
Pancreatic acinar cell tumor
Acinar cystic transformation of the pancreas (acinar cell cystadenoma)
Acinar cell carcinoma (BCL10染色陽性は,BCL10のC末端を認識する抗体が,膵臓のリパーゼのC末端も認識する交差反応による)
mixed acinar carcinoma
mixed acinar-ductal carcinoma
Pancreatoblastoma
Solid-pseudopapillary neoplasm 充実性偽乳頭状腫瘍
Pancreatic neuroendocrine neoplasms (PanNENs)
G1 PanNET, <2/2 mm^2, <3%
G2 PanNET, 2-20, <20%
G3 PanNET, >20, >20%
PanNEC, EMA (MUC1)+, CEA+
Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN)
non-functioning PanNETs
Insulinoma
Gastrinoma
VIPoma
Glucagonoma
Somatostatinoma
ACTH-producing NET
Serotonin-producing NET
================
以下参考 旧分類:
Pancreatic intraepithelial
neoplasia, grade分類 (AJSP 2001)が適応されるのは細径膵管のみ。
PanIN-1A metaplasia (pyloric
gland,
goblet cell) mucinous ductal hyperplasia
tall
columnar, flat
PanIN-1B papillary hyperplasia
tall
columnar, papillary or micropapillary
PanIN-2 atypical hyperplasia
low-grade dysplasia, moderate dysplasia
enlarged nuclei, pseudostratification, flat or papillary
PanIN-3 Carcinoma in situ,
high-grade
dysplasia moderate to severe dysplasia
true
cribriforming, budding, (出芽)luminal necrosis
mitoses,
macronucleoli
Drawing by Jennifer Parsons
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WHO (2010)
Acinar cell cystadenoma
Serous cystadenoama
Pancreatic intraepithelial neoplasia, grade 3 (PanIN-3)
IIPMN with low- or intermediate-grade dysplasia
8453/0
IPMN with high-grade dysplasia 8453/2
Intraductal tubulopapillary neoplasm 8503/2
MCN with low- or intermediate-grade dysplasia
8470/0
MCN with high-grade dysplasia 8470/2
Ductal adenocarcinoma
Adenosquamous ca.
Colloid ca. (mucinous noncystic ca.)
Hepatoid ca.
Medullary ca.
Signet ring cell ca.
Undifferentiated ca.
Undifferentiated ca. with osteoclast-like giant
cells
Acinar cell carcinoma
Acinar cell cystadenocarcinoma
IPMN with an associated invasive carcinoma
8453/3
Mixed acinar-ductal ca.
acinar-neuroendocrine
acinar-neuroendocrine-ductal
ductal-neuroendocrine
MCN with an associated invasive carcinoma 8470/3
Pancreatoblastoma
Serous cystadenocarcinoma
Solid-pseudopapillary neoplasm 8452/3
Panreatic neuroendocrine microadenoma 8150/0
NET G1 8240/3
NET G2 8249/3
Large cell NEC
Small cell NEC
EC cel, serotonin-producing NET (carcinoid)
Gastrinoma
Glucagonoma
Insulinoma
Somatostatinoma
VIPoma
Mature teratoma 9080/0