MALT Wotherspoon Grade (1993)

0: Normal : Scattered plasma cells: no lymphoid follicles

1: Chronic active gastritis: Small clusters of lymphoid cell

in lamina propria: no lymphoid follicles or lymphoepithelial lesion


2: Chronic active gastritis with florid lymphoid follicle
formation
: Prominent lymphoid follicles


3: Suspicious lymphoid infiltrate, probably reactive:

Lymphoid follicles surrounded by small lymphocyte

that infiltrate diffusely in lamina propria and occasionaly into epithelium.


4: Suspicious lymphoid infiltrate, probably lymphoma:

Lymphoid follicles surrouded by CCL cells that infiltrate

diffusely in lamina propria and into epithelium in small groups.


5: Low-grade B-cell MALT lymphoma:
Dense infiltrate of CCL cells in lamina propria; prominent LEL.

Wotherspoon AC et al. Regression of primary low-grade B-cell

gastric lymphoma of mucosa-associated lymphoid tissue type

after eradication of Helicobacter pylori. Lancet. 1993;342:575-577.