Hematolymphoid Tumor Classification
Hematolymphoid Tumor Classification
血液リンパ系腫瘍分類 日本語訳（案）つき
WHO Classification of Tumours Online
2022年9月26日開始 2024年5月4日最終更新
1. Forewords and Introductions
General Introduction
ICCR datasets: Hemopoietic
2. Myeloid proliferations and neoplasms
Myeloid precursor lesions 骨髄性前駆病変
Clonal Hematopoiesis
Introduction
Clonal hematopoiesis クローン性造血
Clonal cytopenias of undetermined significance 意義不明のクローン性血球減少症
Myeloproliferative neoplasms 骨髄増殖性腫瘍 (MPN)
Myeloproliferative neoplasms
Introduction
Chronic myeloid leukemia 慢性骨髄性白血病
Chronic neutrophilic leukemia 慢性好中球性白血病
Chronic eosinophilic leukemia 慢性好酸球性白血病
Polycythemia vera 真性多血症
Essential thrombocythemia 本態性血小板血症
Primary myelofibrosis 原発性骨髄線維症
Juvenile myelomonocytic leukemia 若年性骨髄単球性白血病
Myeloproliferative neoplasm, NOS 骨髄増殖性腫瘍、非特定型
Mastocytosis マスト細胞症
Introduction
Cutaneous mastocytosis 皮膚肥満細胞症
Systemic mastocytosis 全身性肥満細胞症
Mast cell sarcoma 肥満細胞肉腫
Myelodysplastic neoplasms 骨髄異形成腫瘍 (MDS)
Introduction
Myelodysplastic neoplasms, with defining genetic abnormalities 特徴的な遺伝子異常を伴う骨髄異形成腫瘍
Myelodysplastic neoplasm with low blasts and 5q deletion 低芽球比率および 5q 欠失を伴う骨髄異形成腫瘍
Myelodysplastic neoplasm with low blasts and SF3B1 mutation
Myelodysplastic neoplasm with biallelic TP53 inactivation 両アレルのTP53不活性化を伴う骨髄異形成腫瘍
Myelodysplastic neoplasms, morphologically defined 形態学的に定義された骨髄異形成腫瘍
Myelodysplastic neoplasm with low blasts 低芽球比率骨髄異形成腫瘍
Myelodysplastic neoplasm, hypoplastic 低形成骨髄異形成腫瘍
Myelodysplastic neoplasm with increased blasts 芽球増加を伴う骨髄異形成腫瘍
Myelodysplastic neoplasms of childhood 小児期骨髄異形成腫瘍
Childhood myelodysplastic neoplasm with low blasts 低芽球比率骨髄異形成腫瘍
Childhood myelodysplastic neoplasm with increased blasts 芽球増加を伴う小児骨髄異形成腫瘍
Myelodysplastic/myeloproliferative neoplasms 骨髄異形成/骨髄増殖性腫瘍 (MDS/MPN)
Introduction
Chronic myelomonocytic leukemia 慢性骨髄単球性白血病
Myelodysplastic/myeloproliferative neoplasm with neutrophilia 好中球増多を伴う
Myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis
Myelodysplastic/myeloproliferative neoplasm, NOS
Acute myeloid leukemia 急性骨髄性白血病 (AML)
Introduction
Acute myeloid leukemia with defining genetic abnormalities
Acute promyelocytic leukemia with PML::RARA fusion
Acute myeloid leukemia with RUNX1::RUNX1T1 fusion
Acute myeloid leukemia with CBFB::MYH11 fusion
Acute myeloid leukemia with DEK::NUP214 fusion
Acute myeloid leukemia with RBM15::MRTFA fusion
Acute myeloid leukemia with BCR::ABL1 fusion
Acute myeloid leukemia with KMT2A rearrangement
Acute myeloid leukemia with MECOM rearrangement
Acute myeloid leukemia with NUP98 rearrangement
Acute myeloid leukemia with NPM1 mutation
Acute myeloid leukemia with CEBPA mutation
Acute myeloid leukemia, myelodysplasia-related
Acute myeloid leukemia with other defined genetic alterations
Acute myeloid leukemia, defined by differentiation
Acute myeloid leukemia with minimal differentiation
Acute myeloid leukemia without maturation
Acute myeloid leukemia with maturation
Acute basophilic leukemia
Acute myelomonocytic leukemia
Acute monocytic leukemia
Acute erythroid leukemia
Acute megakaryoblastic leukemia
Myeloid sarcoma
Myeloid sarcoma
Myeloid neoplasms, secondary 二次性骨髄性腫瘍
Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions
Introduction
Myeloid neoplasm post cytotoxic therapy 細胞障害性治療後骨髄性腫瘍
Myeloid neoplasms associated with germline predisposition 生殖細胞性素因関連骨髄性腫瘍
Myeloid proliferations associated with Down syndrome ダウン症候群関連骨髄増殖症
Myeloid/lymphoid neoplasms 骨髄性／リンパ性腫瘍
Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement
Introduction
Myeloid/lymphoid neoplasm with PDGFRA rearrangement
Myeloid/lymphoid neoplasm with PDGFRB rearrangement
Myeloid/lymphoid neoplasm with FGFR1 rearrangement FGFR1再構成を伴う骨髄性／リンパ性腫瘍
Myeloid/lymphoid neoplasm with JAK2 rearrangement
Myeloid/lymphoid neoplasm with FLT3 rearrangement
Myeloid/lymphoid neoplasm with ETV6::ABL1 fusion
Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes
Acute leukemias of mixed or ambiguous lineage 混合系統型あるいは分化系統不明瞭な急性白血病
Introduction
Acute leukemia of ambiguous lineage with defining genetic abnormalities
Mixed-phenotype acute leukemia with BCR::ABL1 fusion BCR::ABL1融合を伴う混合表現型急性白血病
Mixed-phenotype acute leukemia with KMT2A rearrangement
Acute leukemia of ambiguous lineage with other defined genetic alterations
Acute leukemia of ambiguous lineage, immunophenotypically defined
Mixed-phenotype acute leukemia, B/myeloid 混合表現型急性白血病、B/骨髄性
Mixed-phenotype acute leukemia, T/myeloid
Mixed-phenotype acute leukemia, rare types
Acute leukemia of ambiguous lineage, NOS
Acute undifferentiated leukemia
3. Histiocytic/Dendritic cell neoplasms 組織球／樹状細胞腫瘍
Introduction
Plasmacytoid dendritic cell neoplasms
Plasmacytoid dendritic cell neoplasms
Mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm 骨髄性腫瘍に伴う成熟形質細胞様樹状細胞増殖
Blastic plasmacytoid dendritic cell neoplasm 芽球性形質細胞様樹状細胞腫瘍 (BPDCN)
Langerhans cell and other dendritic cell neoplasms
Langerhans cells neoplasms
Langerhans cell histiocytosis ランゲルハンス細胞組織球症
Langerhans cell sarcoma ランゲルハンス細胞肉腫
Other dendritic cell neoplasms
Indeterminate dendritic cell tumor 不確定型樹状細胞腫瘍
Interdigitating dendritic cell sarcoma 指状嵌入細胞肉腫
Histiocyte/macrophage neoplasms 組織球／マクロファージ腫瘍
Histiocytic neoplasms
Juvenile xanthogranuloma 若年性黄色肉芽腫
Erdheim-Chester disease エルドハイム・チェスター病
Rosai-Dorfman Disease ロザイ・ドルフマン病
ALK-positive histiocytosis ALK陽性組織球症
Histiocytic sarcoma 組織球肉腫
4. B-cell lymphoid proliferations and lymphomas B細胞リンパ球増殖とリンパ腫
Introduction to B-cell lymphoproliferative disorders and neoplasms
Tumour like lesions with B-cell predominance B細胞優位の腫瘍様病変
Introduction
Reactive B-cell rich lymphoid proliferations that can mimic lymphoma リンパ腫を模倣する反応性B細胞豊富リンパ増殖
IgG4-related disease IgG4関連疾患
Unicentric Castleman disease 単中心性キャッスルマン病
Idiopathic multicentric Castleman disease 特発性多中心性キャッスルマン病
KSHV/HHV8-associated multicentric Castleman disease KSHV/HHV8関連多中心性キャッスルマン病
Precursor B-cell neoplasms 前駆B細胞腫瘍
B-lymphoblastic leukemias/lymphomas Bリンパ芽球性白血病／リンパ腫
Introduction
B-lymphoblastic leukemia/lymphoma
B-lymphoblastic leukemia/lymphoma with high hyperdiploidy
B-lymphoblastic leukemia/lymphoma with hypodiploidy
B-lymphoblastic leukemia/lymphoma with iAMP21
B-lymphoblastic leukemia/lymphoma with BCR::ABL1 fusion
B-lymphoblastic leukemia/lymphoma with BCR::ABL1-like features
B lymphoblastic leukemia/lymphoma with KMT2A rearrangement
B lymphoblastic leukemia/lymphoma with ETV6::RUNX1 fusion
B-lymphoblastic leukemia/lymphoma with ETV6::RUNX1-like features
B lymphoblastic leukemia/lymphoma with TCF3::PBX1 fusion
B lymphoblastic leukemia/lymphoma with IGH::IL3 fusion
B lymphoblastic leukemia/lymphoma with TCF3::HLF fusion
B-lymphoblastic leukemia/lymphoma with other defined genetic alterations
B-lymphoblastic leukemia/lymphoma, NOS
Mature B-cell neoplasms 成熟B細胞腫瘍
Pre-neoplastic and neoplastic small lymphocytic proliferations
Introduction
Monoclonal B-cell lymphocytosis 単クローン性Bリンパ球増加症
Chronic lymphocytic leukemia/small lymphocytic lymphoma 慢性リンパ性白血病／小リンパ球性リンパ腫
Splenic B-cell lymphomas and leukemias
Introduction
Hairy cell leukemia 有毛細胞白血病
Splenic marginal zone lymphoma 脾辺縁帯リンパ腫
Splenic diffuse red pulp small B-cell lymphoma びまん性赤脾髄小型B細胞リンパ腫
Splenic B-cell lymphoma/leukemia with prominent nucleoli 核小体が目立つ脾B細胞リンパ腫／白血病
Lymphoplasmacytic lymphoma
Lymphoplasmacytic lymphoma リンパ形質細胞性リンパ腫
Marginal zone lymphoma
Introduction
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue 粘膜関連リンパ組織型節外性辺縁帯リンパ腫 (MALT リンパ腫)
Primary cutaneous marginal zone lymphoma 原発性皮膚濾胞中心リンパ腫
Nodal marginal zone lymphoma 節性辺縁帯リンパ腫
Paediatric nodal marginal zone lymphoma 小児節性辺縁帯リンパ腫
Follicular lymphoma
Introduction
In situ follicular B-cell neoplasm 原位置濾胞性B細胞腫瘍
Follicular lymphoma 濾胞性リンパ腫
Paediatric-type follicular lymphoma 小児型濾胞性リンパ腫
Duodenal-type follicular lymphoma 十二指腸型濾胞性リンパ腫
Cutaneous follicle centre lymphoma
Primary cutaneous follicle centre lymphoma 原発性皮膚濾胞中心リンパ腫
Mantle cell lymphoma
Introduction
In situ mantle cell neoplasm 原位置マントル細胞腫瘍
Mantle cell lymphoma マントル細胞リンパ腫
leukemic non-nodal mantle cell lymphoma 白血病性非節性マントル細胞リンパ腫
Transformations of indolent B-cell lymphomas
Introduction
Transformations of indolent B-cell lymphomas 低悪性度B細胞リンパ腫の形質転換
Large B-cell lymphomas
Introduction
Diffuse large B-cell lymphoma, NOS びまん性大細胞型B細胞リンパ腫、非特定型
T-cell/histiocyte-rich large B-cell lymphoma T細胞/組織球豊富型大細胞型B細胞リンパ腫
Diffuse
large B-cell lymphoma / high grade B-cell lymphoma with MYC and BCL2
rearrangements MYC および BCL2 再構成を伴うびまん性大細胞型B細胞リンパ腫／高悪性度B細胞リンパ腫
ALK-positive large B-cell lymphoma ALK陽性大細胞型B細胞リンパ腫
Large B-cell lymphoma with IRF4 rearrangement IRF4 再構成を伴う大細胞型B細胞リンパ腫
High grade B-cell lymphoma with 11q aberrations 11q 異常のある高悪性度B細胞リンパ腫
Lymphomatoid granulomatosis リンパ腫様肉芽腫症
EBV-positive diffuse large B-cell lymphoma EBV 陽性びまん性大細胞型B細胞リンパ腫
Diffuse large B-cell lymphoma associated with chronic inflammation 慢性炎症に伴うびまん性大細胞型B細胞リンパ腫
Fibrin-associated large B-cell lymphoma フィブリン関連びまん性大細胞型B細胞リンパ腫
Fluid overload-associated large B-cell lymphoma 体液過剰関連大細胞型B細胞リンパ腫
Plasmablastic lymphoma 形質芽細胞性リンパ腫
Primary large B-cell lymphoma of immune-privileged sites 原発性免疫特権部位大細胞型B細胞リンパ腫
Primary cutaneous diffuse large B-cell lymphoma, leg type 皮膚原発びまん性大細胞型B細胞リンパ腫，下肢型
Intravascular large B-cell lymphoma 血管内大細胞型B細胞リンパ腫
Primary mediastinal large B-cell lymphoma 原発性縦隔大細胞型B細胞リンパ腫
Mediastinal grey zone lymphoma 縦隔グレーゾーンリンパ腫
High-grade B-cell lymphoma, NOS 高悪性度B細胞リンパ腫、非特定型
Burkitt lymphoma
Burkitt lymphoma バーキットリンパ腫
KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas
Introduction
Primary effusion lymphoma 原発性滲出液リンパ腫
KSHV/HHV8-positive diffuse large B-cell lymphoma KSHV/HHV8陽性びまん性大細胞型B細胞リンパ腫
KSHV/HHV8-positive germinotropic lymphoproliferative disorder KSHV/HHV8陽性胚向性リンパ増殖性疾患 (KSVH/HHV8+ GLPD)
Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation 免疫不全および免疫調節障害に伴うリンパ球増殖とリンパ腫
Introduction
Hyperplasias arising in immune deficiency/dysregulation 免疫不全／免疫調節異常に生じる過形成
Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation 免疫不全／免疫調節異常に生じる多形性リンパ増殖性疾患
EBV-positive mucocutaneous ulcer EBV陽性粘膜皮膚潰瘍
Lymphomas arising in immune deficiency / dysregulation 免疫不全／免疫調節異常に生じるリンパ腫
Inborn error of immunity-associated lymphoid proliferations and lymphomas 先天性免疫異常によるリンパ球増殖とリンパ腫
Hodgkin lymphoma
Introduction
Classic Hodgkin lymphoma 古典的ホジキンリンパ腫 (CHL)
Nodular lymphocyte predominant Hodgkin lymphoma 結節性リンパ球優位型ホジキンリンパ腫 (NLPHL)
Plasma cell neoplasms and other diseases with paraproteins
Introduction
Monoclonal gammopathies
Cold agglutinin disease 寒冷凝集素症
IgM monoclonal gammopathy of undetermined significance 意義不明の IgM 単クローン性ガンマグロブリン血症
Non-IgM monoclonal gammopathy of undetermined significance 意義不明の非 IgM 単クローン性ガンマグロブリン血症
Monoclonal gammopathy of renal significance 腎障害を伴う単クローン性ガンマグロブリン血症
Diseases with monoclonal immunoglobulin deposition
Immunoglobulin-related (AL) amyloidosis 免疫グロブリン関連 (AL) アミロイドーシス
Monoclonal immunoglobulin deposition disease 単クローン性免疫グロブリン沈着病
Heavy chain diseases
Introduction
Mu heavy chain disease μ重鎖病
Gamma heavy chain disease γ重鎖病
Alpha heavy chain disease α重鎖病
Plasma cell neoplasms
Introduction
Plasmacytoma 形質細胞腫
Plasma cell myeloma / multiple myeloma 形質細胞骨髄腫／多発性骨髄腫
Plasma cell neoplasms with associated paraneoplastic syndrome 腫瘍随伴症候群関連形質細胞腫瘍
5. T-cell and NK-cell lymphoid proliferations and lymphomas T細胞性およびNK細胞性のリンパ球増殖およびリンパ腫
Introduction
Tumour-like lesions with T-cell predominance T細胞優位の腫瘍様病変
Kikuchi-Fujimoto disease 菊池・藤本病
Autoimmune lymphoproliferative syndrome 自己免疫性リンパ増殖症候群 (ALPS)
Indolent T-lymphoblastic proliferation 緩徐進行性Tリンパ芽球増殖症
Precursor T-cell neoplasms 前駆T細胞腫瘍
T-lymphoblastic leukemia / lymphoma
T-lymphoblastic leukemia / lymphoma, NOS Tリンパ芽球性白血病／リンパ腫、非特定型
Early T-precursor lymphoblastic leukemia / lymphoma 早期T前駆リンパ芽球性白血病／リンパ腫
Mature T-cell and NK-cell neoplasms
Mature T-cell and NK-cell leukemias
Introduction
T-prolymphocytic leukemia T細胞前リンパ球性白血病
T-large granular lymphocytic leukemia T細胞大顆粒リンパ球性白血病
NK-large granular lymphocytic leukemia NK細胞大顆粒リンパ球性白血病
Adult T-cell leukemia/lymphoma 成人T細胞白血病・リンパ腫
Sezary syndrome セザリー症候群
Aggressive NK-cell leukemia 急速進行性NK細胞白血病
Primary cutaneous T-cell lymphoid proliferations and lymphomas
Introduction to primary cutaneous T-cell neoplasms
Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder 原発性皮膚CD4陽性小型・中型T細胞リンパ増殖異常症
Primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder 原発性皮膚末端性CD8陽性T細胞リンパ増殖異常症
Mycosis fungoides 菌状息肉症
Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis 原発性皮膚CD30陽性T細胞リンパ増殖異常症：リンパ腫様丘疹症
Primary
cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary
cutaneous anaplastic large cell
lymphoma 原発性皮膚CD30陽性T細胞リンパ増殖異常症：原発性皮膚未分化大細胞リンパ腫
Subcutaneous panniculitis-like T-cell lymphoma 皮下脂肪織炎様T細胞リンパ腫
Primary cutaneous gamma/delta T-cell lymphoma 原発性皮膚γδT細胞リンパ腫
Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma 原発性皮膚CD8陽性アグレッシブ表皮向性細胞障害性T細胞リンパ腫
Primary cutaneous peripheral T-cell lymphoma, NOS 原発性皮膚末梢性T細胞リ ンパ腫、非特定型
Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas
Introduction
Indolent T-cell lymphoma of the gastrointestinal tract 緩徐進行性消化管T細胞リンパ腫
Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract 緩徐進行性消化管NK細胞性リンパ増殖異常症
Enteropathy-associated T-cell lymphoma 腸管症関連T細胞リンパ腫
Monomorphic epitheliotropic intestinal T-cell lymphoma 単形性上皮向性腸管T細胞リンパ腫
Intestinal T-cell lymphoma, NOS 腸管T細胞リンパ腫、非特定型
Hepatosplenic T-cell lymphoma
Hepatosplenic T-cell lymphoma 肝脾T細胞リンパ腫
Anaplastic large cell lymphoma
Introduction
ALK-positive anaplastic large cell lymphoma ALK陽性未分化大細胞リンパ腫
ALK-negative anaplastic large cell lymphoma ALK陰性未分化大細胞リンパ腫
Breast implant-associated anaplastic large cell lymphoma 乳房インプラント関連未分化大細胞リンパ腫
Nodal T-follicular helper (TFH) cell lymphoma
Introduction
Nodal TFH cell lymphoma, angioimmunoblastic-type 節性濾胞ヘルパー T細胞リンパ腫、血管免疫芽球型
血管免疫芽球性T細胞リンパ腫
Nodal TFH cell lymphoma, follicular-type 節性濾胞ヘルパー T細胞リンパ腫、濾胞型
Nodal TFH cell lymphoma, NOS 節性濾胞ヘルパーT細胞リンパ腫、非特定型
Other peripheral T-cell lymphomas
Peripheral T-cell lymphoma, NOS 末梢性T細胞リンパ腫、非特定型
EBV-positive NK-cell and T-cell lymphomas
EBV-positive nodal T- and NK-cell lymphoma EBV陽性節性T細胞およびNK細胞リンパ腫
Extranodal NK/T-cell lymphoma 節外性NK/T細胞リンパ腫
EBV-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood 小児期のEBV陽性T細胞およびNK細胞リンパ球像増殖とリンパ腫
Introduction
Severe mosquito bite allergy 重症蚊アレルギー
Hydroa vacciniforme lymphoproliferative disorder 種痘様水疱症類似リンパ増殖異常症
Systemic chronic active EBV disease 全身性慢性活動性EBV感染症
Systemic EBV-positive T-cell lymphoma of childhood 小児期全身性EBV陽性T細胞リンパ腫
6. Stroma-derived neoplasms of lymphoid tissues リンパ組織の間質由来腫瘍
Introduction
Mesenchymal dendritic cell neoplasms
Follicular dendritic cell neoplasms
Follicular dendritic cell sarcoma 濾胞樹状細胞肉腫
EBV-positive inflammatory follicular dendritic cell sarcoma EBV陽性炎症性濾胞樹状細胞肉腫
Fibroblastic reticular cell tumor 線維芽網状細胞腫瘍
Myofibroblastic tumours
Myofibroblastic tumor
Intranodal palisaded myofibroblastoma 節内柵状筋線維芽腫
Spleen-specific vascular-stromal tumours
Splenic vascular-stromal tumours
Littoral cell angioma 沿岸細胞血管腫
Splenic hamartoma 脾過誤腫
Sclerosing angiomatoid nodular transformation (SANT) of spleen 脾臓の硬化性血管腫様結節性形質転換