Head and Neck Tumours (WHO/IARC腫瘍分類 第4版 第9巻による)

1. Tumours of the nasal cavity, paranasal sinuses and skull base
Carcinomas
    Keratinizing squamous cell carcinoma
    Non-keratinizing squamous cell carcinoma
    Spindle cell (sarcomatoid) squamous cell carcinoma
    Lymphoepithelial carcinoma
    Sinonasal undifferentiated carcinoma
    NUT carcinoma
    Neuroendocrine carcinoma
    Adenocarcinoma
        Intestinal-type adenocarcinoma
        Non–intestinal-type adenocarcinoma

Teratocarcinosarcoma

Sinonasal papillomas
    Sinonasal papilloma, inverted type
    Sinonasal papilloma, oncocytic type
    Sinonasal papilloma, exophytic type

Respiratory epithelial lesions
    Respiratory epithelial adenomatoid hamartoma
    Seromucinous hamartoma

Salivary gland tumours
    Pleomorphic adenoma

Malignant soft tissue tumours
    Fibrosarcoma
    Undifferentiated pleomorphic sarcoma
    Leiomyosarcoma
    Rhabdomyosarcoma
    Angiosarcoma
    Malignant peripheral nerve sheath tumour
    Biphenotypic sinonasal sarcoma
    Synovial sarcoma

Borderline / low-grade malignant soft tissue tumours
    Desmoid-type fibromatosis
    Sinonasal glomangiopericytoma
    Solitary fibrous tumour
    Epithelioid haemangioendothelioma

Benign soft tissue tumours
    Leiomyoma
    Haemangioma
    Schwannoma
    Neurofibroma  

Other tumours
    Meningioma
    Sinonasal ameloblastoma
    Chondromesenchymal hamartoma

Haematolymphoid tumours
    Extranodal NK/T-cell lymphoma
    Extraosseous plasmacytoma

Neuroectodermal / melanocytic tumours
    Ewing sarcoma/primitive neuroectodermal tumours
    Olfactory neuroblastoma
    Mucosal melanoma


2. Tumours of the nasopharynx
Nasopharyngeal carcinoma
Nasopharyngeal papillary adenocarcinoma

Salivary gland tumours
    Adenoid cystic carcinoma
    Salivary gland anlage tumour

Benign and borderline lesions
    Hairy polyp
    Ectopic pituitary adenoma

Craniopharyngioma

Soft tissue tumours
    Nasopharyngeal angiofibroma

Haematolymphoid tumours

Notochordal tumours
    Chordoma


3. Tumours of the hypopharynx, larynx, trachea and parapharyngeal space
Malignant surface epithelial tumours
    Conventional squamous cell carcinoma
    Verrucous squamous cell carcinoma
    Basaloid squamous cell carcinoma
    Papillary squamous cell carcinoma
    Spindle cell squamous cell carcinoma
    Adenosquamous carcinoma
    Lymphoepithelial carcinoma

Precursor lesions
    Dysplasia
    Squamous cell papilloma & squamous cell papillomatosis

Neuroendocrine tumours
    Well-differentiated neuroendocrine carcinoma
    Moderately differentiated neuroendocrine carcinoma
    Poorly differentiated neuroendocrine carcinoma

Salivary gland tumours
    Adenoid cystic carcinoma
    Pleomorphic adenoma
    Oncocytic papillary cystadenoma

Soft tissue tumours
    Granular cell tumour
    Liposarcoma
    Inflammatorymyofibroblastictumour

Cartilage tumours
    Chondroma and chondrosarcoma

Haematolymphoid tumours


4. Tumours of the oral cavity and mobile tongue
Malignant surface epithelial tumours
    Squamous cell carcinoma
Oral potentially malignant disorders & oral epithelial dysplasia
    Oral potentially malignant disorders
    Oral epithelial dysplasia
    Proliferative verrucous leukoplakia

Papillomas
    Squamous cell papilloma
    Condyloma acuminatum
    Verruca vulgaris
    Multifocal epithelial hyperplasia

Tumours of uncertain histogenesis
    Congenital granular cell epulis
    Ectomesenchymal chondromyxoid tumour

Soft tissue and neural tumours
    Granular cell tumour
    Rhabdomyoma
    Lymphangioma
    Haemangioma
    Schwannoma and neurofibroma
    Kaposi sarcoma
    Myofibroblastic sarcoma

Oral mucosal melanoma

Salivary type tumours
    Mucoepidermoid carcinoma
    Pleomorphic adenoma

Haematolymphoid tumours
    CD30-positive T-cell lymphoproliferative disorder
    Plasmablastic lymphoma
    Langerhans cell histiocytosis
    Extramedullary myeloid sarcoma


5. Tumours of the oropharynx (base of tongue, tonsils, adenoids)
Squamous cell carcinoma
    Squamous cell carcinoma, HPV-positive
    Squamous cell carcinoma, HPV-negative

Salivary gland tumours
    Pleomorphic adenoma
    Adenoid cystic carcinoma
    Polymorphous adenocarcinoma

Haematolymphoid tumours
    Hodgkin lymphoma
    Burkitt lymphoma
    Follicular lymphoma
    Mantle cell lymphoma
    T-lymphoblastic leukaemia/lymphoma
    Follicular dendritic cell sarcoma


6. Tumours and tumour-like lesions of the neck and lymph nodes
Tumours of unknown origin
    Carcinoma of unknown primary
    Merkel cell carcinoma
    Heterotopia-associated carcinoma

Haematolymphoid tumours

Cysts and cyst-like lesions
    Branchial cleft cyst
    Thyroglossal duct cyst
    Ranula
    Dermoid and teratoid cysts


7. Tumours of salivary glands
Malignant tumours
    Mucoepidermoid carcinoma
    Adenoid cystic carcinoma
    Acinic cell carcinoma
    Polymorphous adenocarcinoma
    Clear cell carcinoma
    Basal cell adenocarcinoma
    Intraductal carcinoma
    Adenocarcinoma, NOS
    Salivary duct carcinoma
    Myoepithelial carcinoma
    Epithelial–myoepithelial carcinoma
    Carcinoma ex pleomorphic adenoma
    Secretory carcinoma
    Sebaceous adenocarcinoma
    Carcinosarcoma
    Poorly differentiated carcinoma
    Lymphoepithelial carcinoma
    Squamous cell carcinoma
    Oncocytic carcinoma
    Sialoblastoma

Benign tumours
    Pleomorphic adenoma
    Myoepithelioma
    Basal cell adenoma
    Warthin tumour
    Oncocytoma
    Lymphadenoma
    Cystadenoma
    Sialadenoma papilliferum
    Ductal papillomas
    Sebaceous adenoma
    Canalicular adenoma and other ductal adenomas

Non-neoplastic epithelial lesions
    Sclerosing polycystic adenosis
    Nodular oncocytic hyperplasia
    Lymphoepithelial sialadenitis
    Intercalated duct hyperplasia

Benign soft tissue lesions
    Haemangioma
    Lipoma/sialolipoma Nodular fasciitis

Haematolymphoid tumours
    Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)


8. Odontogenic and maxillofacial bone tumours
Odontogenic carcinomas
    Ameloblastic carcinoma
    Primary intraosseous carcinoma, NOS
    Sclerosing odontogenic carcinoma
    Clear cell odontogenic carcinoma
    Ghost cell odontogenic carcinoma

Odontogenic carcinosarcoma

Odontogenic sarcomas

Benign epithelial odontogenic tumours
    Ameloblastoma
        Ameloblastoma, unicystic type
        Ameloblastoma, extraosseous/peripheral type 
        Metastasizing ameloblastoma
    Squamous odontogenic tumour
    Calcifying epithelial odontogenic tumour
    Adenomatoid odontogenic tumour

Benign mixed epithelial & mesenchymal odontogenic tumours
    Ameloblastic fibroma
    Primordial odontogenic tumour
    Odontoma
    Dentinogenic ghost cell tumour 

Benign mesenchymal odontogenic tumours 
    Odontogenic fibroma
    Odontogenic myxoma/myxofibroma 
    Cementoblastoma
    Cemento-ossifying fibroma

Odontogenic cysts of inflammatory origin
    Radicular cyst
    Inflammatory collateral cysts 

Odontogenic and non-odontogenic developmental cysts
    Dentigerous cyst
    Odontogenic keratocyst
    Lateral periodontal cyst and botryoid odontogenic cyst 
    Gingival cysts
    Glandular odontogenic cyst
    Calcifying odontogenic cyst
    Orthokeratinized odontogenic cyst
    Nasopalatine duct cyst 

Malignant maxillofacial bone and cartilage tumours 
    Chondrosarcoma
    Mesenchymal chondrosarcoma
    Osteosarcoma

Benign maxillofacial bone and cartilage tumours 
    Chondroma
    Osteoma

Melanotic neuroectodermal tumour of infancy 
    Chondroblastoma
    Chondromyxoid fibroma
    Osteoid osteoma
    Osteoblastoma
    Desmoplastic fibroma

Fibro-osseous and osteochondromatous lesions 
    Ossifying fibroma
    Familial gigantiform cementoma
    Fibrous dysplasia
    Cemento-osseous dysplasia
    Osteochondroma 

Giant cell lesions and simple bone cyst
    Central giant cell granuloma
    Peripheral giant cell granuloma
    Cherubism
    Aneurysmal bone cyst
    Simple bone cyst

Haematolymphoid tumours
    Solitary plasmacytoma of bone


9. Tumours of the ear
Tumours of the external auditory canal
    Squamous cell carcinoma
    Ceruminous adenocarcinoma
    Ceruminous adenoma

Tumours of the middle and inner ear
    Squamous cell carcinoma
    Aggressive papillary tumour
    Endolymphatic sac tumour
    Otosclerosis
    Cholesteatoma
    Vestibular schwannoma
    Meningioma
    Middle ear adenoma


10. Paraganglion tumours
    Carotid body paraganglioma
    Laryngeal paraganglioma
    Middle ear paraganglioma
    Vagal paraganglioma