Endometrial dating (Noyes
et al.
Fertility and sterility 1950)
Proliferative phase - straight/edema/coiled
Early secretory phase (POD 2-5)
2: Uniform subnuclear vacuolization (≥50%),
pseudostratification,
frequent
mitoses
3: subnuclear vacuole+, nuclear uniformity, scattered mitoses
4: luminal vacuole+,
rare
mitoses
5: infrequent vacuole, secretion
Midsecretory phase (POD 6-8): no vacuole, no decidua
6: prominent
secretion
7: early stromal edema
8: maximal stromal adema
Late secretory phase (POD 9-14)
9: spiral artery prominent
10: periarterial predecidua
11: islands of predecidua
12: coalescent predecidua
13: confluent decidua, granulocytes prominent
14: extravasation
Menstruation - Crumbing of stroma, thrombi
Considering as out-of-phase a delay of 3 days or more.
Recent study suggests that simple histological evaluation is
not a valid measure of the
quality
of luteal function or endometrial receptivity.
Would be useful to
exclude neoplasm or infection.