- Female Genital Tumours (5th ed.)
- 1. Foreword
WHO Classification of Tumours: Editorial Board
How to cite this volume
Foreword with changes from the book, including corrigenda
WHO classification of tumours of the female genital tract: ICD-O coding
General introduction
- 2. Tumours of the ovary
Tumours of the ovary: Introduction
Serous tumours
Benign serous tumours
Serous cystadenoma, adenofibroma, and surface papilloma of the ovary
Borderline serous tumours
Serous borderline tumour of the ovary
Malignant serous tumours
Low-grade serous carcinoma of the ovary
High-grade serous carcinoma of the ovary
Mucinous tumours
Benign mucinous tumours
Mucinous cystadenoma and adenofibroma
Borderline mucinous tumours
Mucinous borderline tumour
Malignant mucinous tumours
Mucinous carcinoma of the ovary
Endometrioid tumours
Benign endometrioid tumours
Endometrioid cystadenoma and adenofibroma
Borderline endometrioid tumours
Endometrioid borderline tumour
Malignant endometrioid tumours
Endometrioid carcinoma of the ovary
Clear cell tumours
Benign clear cell tumours
Clear cell cystadenoma and adenofibroma
Borderline clear cell tumours
Clear cell borderline tumour
Malignant clear cell tumours
Clear cell carcinoma of the ovary
Seromucinous tumours
Benign seromucinous tumours
Seromucinous cystadenoma and adenofibroma
Borderline seromucinous tumours
Seromucinous borderline tumour
Malignant seromucinous tumours
Seromucinous carcinoma
Brenner tumours
Benign Brenner tumours
Brenner tumour
Borderline Brenner tumours
Borderline Brenner tumour
Malignant Brenner tumours
Malignant Brenner tumour
Other carcinomas
Mesonephric-like adenocarcinoma
Undifferentiated and dedifferentiated carcinomas of the ovary
Carcinosarcoma of the ovary
Mixed carcinoma of the ovary
Mesenchymal tumours
Endometrioid stromal sarcoma of the ovary
Smooth muscle tumours of the ovary
Ovarian myxoma
Other ovarian mesenchymal tumours
Mixed epithelial and mesenchymal tumours
Mixed malignant epithelial and mesenchymal tumours
Adenosarcoma of the ovary
Sex cord-stromal tumours
Pure stromal tumours
Ovarian fibroma
Thecoma
Luteinized thecoma associated with sclerosing peritonitis
Sclerosing stromal tumour
Microcystic stromal tumour
Signet-ring stromal tumour
Leydig cell tumour
Steroid cell tumour
Ovarian fibrosarcoma
Pure sex cord tumours
Adult granulosa cell tumour
Juvenile granulosa cell tumour
Sertoli cell tumour
Sex cord tumour with annular tubules
Mixed sex cord-stromal tumours
Sertoli-Leydig cell tumour
Sex cord-stromal tumour NOS
Gynandroblastoma
Germ cell tumours
Mature teratoma of the ovary
Immature teratoma of the ovary
Dysgerminoma
Yolk sac tumour
Embryonal carcinoma
Non-gestational choriocarcinoma
Mixed germ cell tumour of the ovary
Monodermal teratomas and somatic-type tumours arising from a dermoid cyst
Struma ovarii
Ovarian carcinoid
Neuroectodermal-type tumours
Monodermal cystic teratoma
Somatic neoplasms arising from teratomas
Germ cell-sex cord-stromal tumours
Gonadoblastoma
Mixed germ cell-sex cord-stromal tumour, unclassified
Miscellaneous tumours
Rete cystadenoma, adenoma, and adenocarcinoma
Wolffian tumour of the ovary
Solid pseudopapillary tumour
Small cell carcinoma of the ovary, hypercalcaemic type
Wilms tumour
Mesothelial tumours (see Tumours of the peritoneum)
Tumour-like lesions
Follicle cyst
Corpus luteum cyst
Large solitary luteinized follicle cyst
Hyperreactio luteinalis
Pregnancy luteoma
Stromal hyperplasia and hyperthecosis
Fibromatosis and massive oedema
Leydig cell hyperplasia
Metastases
Metastases to the ovary
- 3. Endometriosis and related conditions
Endometriosis and derived tumours
- 4. Tumours of the peritoneum
Tumours of the peritoneum: Introduction
Mesothelial tumours
Adenomatoid tumour
Well-differentiated papillary mesothelial tumour
Mesothelioma
Epithelial tumours
Epithelial tumours of Mullerian type
Serous borderline tumour of the peritoneum
Low-grade serous carcinoma of the peritoneum
High-grade serous carcinoma of the peritoneum
Mesenchymal tumours specific to peritoneum
Smooth muscle tumours
Leiomyomatosis peritonealis disseminata
Miscellaneous primary tumours
Desmoid fibromatosis
Calcifying fibrous tumour
Extragastrointestinal stromal tumour
Solitary fibrous tumour of the peritoneum
Endometrioid stromal sarcoma of the peritoneum
Desmoplastic small round cell tumour
Tumour-like lesions
Mesothelial hyperplasia
Peritoneal inclusion cysts
Transitional cell metaplasia
Endosalpingiosis of the peritoneum
Histiocytic nodule
Ectopic decidua
Splenosis
Other tumour-like lesions of the peritoneum
Metastases
Carcinomas and sarcomas metastatic to the peritoneum
Pseudomyxoma peritonei
Gliomatosis
- 5. Tumours of the fallopian tube
Tumours of the fallopian tube: Introduction
Epithelial tumours
Benign serous tumours
Serous adenofibroma and papilloma of the fallopian tube
Borderline serous tumours
Serous borderline tumour of the fallopian tube
Malignant epithelial tumours
High-grade serous carcinoma of the fallopian tube
Endometrioid carcinoma of the fallopian tube
Carcinosarcoma of the fallopian tube
Tumour-like lesions
Paratubal cysts
Tubal hyperplasia
Tubo-ovarian abscess
Salpingitis isthmica nodosa
Metaplastic papillary lesion
Placental site nodule occurring in the fallopian tube
Mucinous metaplasia
Endosalpingiosis of the fallopian tube
Mixed epithelial and mesenchymal tumours
Adenosarcoma of the fallopian tube
Germ cell tumours
Teratoma of the fallopian tube
- 6. Tumours of the broad ligament and other uterine ligaments
Tumours of the broad ligament and other uterine ligaments: Introduction
Mesenchymal and mixed tumours
Leiomyoma of the broad ligament and other uterine ligaments
Adenomyoma of the broad ligament and other uterine ligaments
Adenosarcoma of the broad ligament and other uterine ligaments
Leiomyosarcoma of the broad ligament and other uterine ligaments
Other mesenchymal and mixed tumours of the broad ligament and other uterine ligaments
Miscellaneous tumours
Wolffian tumour of the broad ligament and other uterine ligaments
Papillary cystadenoma
Ependymoma
Tumour-like lesions
Adrenocortical remnants
- 7. Tumours of the uterine corpus
Tumours of the uterine corpus: Introduction
Endometrial epithelial tumours and precursors
Precursor lesions
Endometrial hyperplasia without atypia
Endometrial atypical hyperplasia / endometrioid intraepithelial neoplasia
Endometrial carcinomas
Endometrioid carcinoma of the uterine corpus
Serous carcinoma of the uterine corpus
Clear cell carcinoma of the uterine corpus
Undifferentiated and dedifferentiated carcinomas of the uterine corpus
Mixed carcinoma of the uterine corpus
Other endometrial carcinomas
Carcinosarcoma of the uterine corpus
Tumour-like lesions
Tumour-like lesions
Endometrial polyp
Endometrial metaplasia
Arias-Stella reaction of the uterine corpus
Mesenchymal tumours of the uterus
Smooth muscle tumours
Uterine leiomyoma
Intravenous leiomyomatosis
Smooth muscle tumour of uncertain malignant potential of the uterine corpus
Metastasizing leiomyoma
Uterine leiomyosarcoma
Endometrial stromal and related tumours
Endometrial stromal nodule
Low-grade endometrial stromal sarcoma
High-grade endometrial stromal sarcoma
Undifferentiated uterine sarcoma
Miscellaneous mesenchymal tumours
Uterine tumour resembling ovarian sex cord tumour
Perivascular epithelioid cell tumour (PEComa)
Inflammatory myofibroblastic tumour
Other mesenchymal tumours of the uterus
Mixed epithelial and mesenchymal tumours
Mixed epithelial and mesenchymal tumours
Adenomyoma of the uterine corpus
Atypical polypoid adenomyoma
Adenosarcoma of the uterine corpus
Miscellaneous tumours
Central primitive neuroectodermal tumour / CNS embryonal tumour
Germ cell tumours of the uterine corpus
- 8. Gestational trophoblastic disease
Gestational trophoblastic disease: Introduction
Tumour-like lesions
Non-neoplastic lesions
Exaggerated placental site reaction
Placental site nodule and plaque
Abnormal (non-molar) villous lesions
Molar pregnancies
Molar pregnancies
Partial hydatidiform mole
Complete hydatidiform mole
Invasive and metastatic hydatidiform moles
Gestational trophoblastic neoplasms
Gestational trophoblastic neoplasms
Epithelioid trophoblastic tumour
Placental site trophoblastic tumour
Gestational choriocarcinoma
Mixed trophoblastic tumour
- 9. Tumours of the uterine cervix
Tumours of the uterine cervix: Introduction
Squamous epithelial tumours
Mimics of squamous precursor lesions
Squamous metaplasia
Atrophy of the uterine cervix
Squamous cell tumours and precursors
Condyloma acuminatum (see Tumours of the vulva)
Squamous intraepithelial lesions of the uterine cervix
Squamous cell carcinoma, HPV-associated, of the uterine cervix
Squamous cell carcinoma, HPV-independent, of the uterine cervix
Squamous cell carcinoma NOS of the uterine cervix
Glandular tumours and precursors
Benign glandular lesions
Endocervical polyp
Mullerian papilloma of the uterine cervix
Nabothian cyst
Tunnel clusters
Microglandular hyperplasia
Lobular endocervical glandular hyperplasia
Diffuse laminar endocervical hyperplasia
Mesonephric remnants and hyperplasia
Arias-Stella reaction of the uterine cervix
Endocervicosis of the uterine cervix
Tuboendometrioid metaplasia
Ectopic prostate tissue
Adenocarcinomas
Adenocarcinoma in situ, HPV-associated, of the uterine cervix
Adenocarcinoma, HPV-associated, of the uterine cervix
Adenocarcinoma in situ, HPV-independent, of the uterine cervix
Adenocarcinoma, HPV-independent, gastric type, of the uterine cervix
Adenocarcinoma, HPV-independent, clear cell type, of the uterine cervix
Adenocarcinoma, HPV-independent, mesonephric type, of the uterine cervix
Other adenocarcinomas of the uterine cervix
Other epithelial tumours
Carcinosarcoma of the uterine cervix
Adenosquamous and mucoepidermoid carcinomas of the uterine cervix
Adenoid basal carcinoma of the uterine cervix
Carcinoma of the uterine cervix, unclassifiable
Mixed epithelial and mesenchymal tumours
Mixed epithelial and mesenchymal tumours
Adenomyoma of the uterine cervix
Adenosarcoma of the uterine cervix
Germ cell tumours
Germ cell tumours of the uterine cervix
- 10. Tumours of the vagina
Tumours of the vagina: Introduction
Epithelial tumours
Benign squamous lesions
Condyloma acuminatum (see Tumours of the vulva)
Squamous papilloma of the vagina
Atrophy of the vagina
Tubulosquamous polyp
Squamous cell tumours and precursors
Squamous intraepithelial lesions of the vagina
Squamous cell carcinoma, HPV-associated, of the vagina
Squamous cell carcinoma, HPV-independent, of the vagina
Squamous cell carcinoma NOS of the vagina
Benign glandular lesions
Villous adenoma
Mullerian papilloma of the vagina
Vaginal adenosis
Endocervicosis of the vagina
Cysts of the vagina
Glandular tumours
Adenocarcinoma, HPV-associated, of the vagina
Endometrioid carcinoma of the vagina
Clear cell carcinoma of the vagina
Mucinous carcinoma, gastric type, of the vagina
Mucinous carcinoma, intestinal type, of the vagina
Mesonephric adenocarcinoma of the vagina
Carcinosarcoma of the vagina
Other epithelial tumours
Mixed tumour of the vagina
Adenocarcinoma of Skene gland origin
Adenosquamous carcinoma of the vagina
Adenoid basal carcinoma of the vagina
Mixed epithelial and mesenchymal tumours
Adenosarcoma of the vagina
Miscellaneous tumours
Germ cell tumours of the vagina
- 11. Tumours of the vulva
Tumours of the vulva: Introduction
Epithelial tumours
Benign squamous lesions
Seborrhoeic keratosis
Condyloma acuminatum
Squamous cell tumours and precursors
Squamous intraepithelial lesions, HPV-associated, of the vulva
Vulvar intraepithelial neoplasia, HPV-independent
Squamous cell carcinoma, HPV-associated, of the vulva
Squamous cell carcinoma, HPV-independent, of the vulva
Squamous cell carcinoma NOS of the vulva
Basal cell carcinoma
Glandular tumours and cysts
Mammary-type glandular lesions
Papillary hidradenoma
Chondroid syringoma
Fibroadenoma
Phyllodes tumour
Adenocarcinoma of mammary gland type
Bartholin gland lesions
Bartholin gland cyst
Bartholin gland hyperplasia, adenoma, and adenomyoma
Bartholin gland carcinomas
Other cysts of the vulva
Adenocarcinomas of other types
Paget disease
Carcinomas of sweat gland origin
Adenocarcinoma of intestinal type
Germ cell tumours
Germ cell tumours of the vulva
- 12. Neuroendocrine neoplasia
Neuroendocrine neoplasia: Introduction
Neuroendocrine tumour
Neuroendocrine tumour
Neuroendocrine carcinoma
Small cell neuroendocrine carcinoma
Large cell neuroendocrine carcinoma
Mixed neuroendocrine-non-neuroendocrine neoplasms
Carcinoma admixed with neuroendocrine carcinoma
- 13. Haematolymphoid proliferations and neoplasia
Haematolymphoid proliferations and neoplasia: Introduction
Reactive lymphoid hyperplasia
Florid reactive lymphoid hyperplasia
Lymphomas
Diffuse large B-cell lymphoma
Extranodal marginal zone lymphoma
Follicular lymphoma
Burkitt lymphoma
Myeloid leukaemia
Myeloid sarcoma
- 14. Mesenchymal tumours of the lower genital tract
Mesenchymal tumours of the lower genital tract: Introduction
Adipocytic tumours
Lipoma
Lipoblastoma-like tumour of the vulva
Liposarcoma
Fibroblastic and myofibroblastic tumours
Postoperative spindle cell nodule
Fibroepithelial stromal polyp
Prepubertal fibroma
Superficial myofibroblastoma
Myofibroblastoma
Cellular angiofibroma
Angiomyofibroblastoma
Solitary fibrous tumour of the lower genital tract
Dermatofibrosarcoma protuberans
NTRK-rearranged spindle cell neoplasm (emerging)
Vascular tumours
Kaposi sarcoma
Angiosarcoma
Smooth muscle tumours
Leiomyoma of the lower genital tract
Smooth muscle tumour of uncertain malignant potential of the lower genital tract
Leiomyosarcoma of the lower genital tract
Skeletal muscle tumours
Rhabdomyoma
Rhabdomyosarcoma
Peripheral nerve sheath tumours
Benign peripheral nerve sheath tumours
Granular cell tumour
Tumours of uncertain differentiation
Superficial angiomyxoma
Deep (aggressive) angiomyxoma
Epithelioid sarcoma
Alveolar soft part sarcoma
Undifferentiated small round cell sarcomas
Ewing sarcoma
- 15. Melanocytic lesions
Naevi
Acquired melanocytic naevus
Congenital melanocytic naevus
Blue naevus
Atypical melanocytic naevus of genital type
Dysplastic melanocytic naevus
Melanoma
Mucosal melanoma
- 16. Metastasis
Metastasis to the lower female genital tract
- 17. Genetic tumour syndromes of the female genital tract
BRCA1/2-associated hereditary breast and ovarian cancer syndrome
Lynch syndrome
Cowden syndrome
Li-Fraumeni syndrome
Peutz-Jeghers syndrome
Ataxia-telangiectasia
Carney complex
DICER1 syndrome
Ovarian dysgenesis
Von Hippel-Lindau syndrome
Hereditary leiomyomatosis and renal cell carcinoma
Other genetic tumour syndromes of the female genital tract