Pheochromocytoma of the Adrenal Gland Scoring Scale (PASS)

Feature
 Score
Large nests or diffuse growth >10%@
’Κν ‚Μ"zellballen"‚π’΄‚¦‚ι‘εŒ^–E‘ƒ 		2
Central or confluent tumor necrosis@‰σŽ€
 2
High cellularity@‚‚’Χ–E–§“x...‹qŠΟ«?
 2
Cellular monotony ’P’²‚ȍזE‘B
 2
Tumor cell spindling even if focal@–aŽŒ`Χ–E
 2
Mitotic figures >3/10 high-power field
•ͺ—τ‘œ‘½‚’
 2
Atypical mitotic figures ˆΩν•ͺ—τ‘œ
 2
Extension into adipose tissue@Ž‰–bDZ
 2
Vascular invasion ŒŒŠΗ‚Ε‚ΰƒŠƒ“ƒpŠΗ‚Ε‚ΰ
 1
Capsular invasion@”ν–ŒZ
 1
Profound nuclear pleomorphism ’˜–Ύ‚ΘŠj‘½Œ`«
e.g. Neoplastic giant cells with >4 µm nucleoli, intranuclear inclusion, hyaline cytoplasmic globules
 1
Nuclear hyperchromasia;
complete opacification and heavy nuclear chromatin deposition
 1
Total
20
PASS of <4 benign
PASS of ≥4 malignant

L. D. R. THOMPSON Am J Surg Pathol, Vol. 26, No. 5, 2002


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